Landmark Clinical Trials: Critical Care

Area:

	Area	Topic	Trial Name	Wiki Journal Club
	Fluid Management	A Comparison of Albumin and Saline for Fluid Resuscitation in the Intensive Care Unit	SAFE	https://www.wikijournalclub.org/wiki/SAFE
	Cardiac Intensive Care	A comparison of rate control and rhythm control in patients with atrial fibrillation.	AFFIRM	https://www.wikijournalclub.org/wiki/AFFIRM
	Cardiac Intensive Care	Apixaban versus warfarin in patients with atrial fibrillation	ARISTOTLE	https://www.wikijournalclub.org/wiki/ARISTOTLE
	Hemodynamics	Application of the Third International Consensus Definitions for Sepsis (Sepsis-3) Classification: a retrospective population-based cohort study	SEPSIS-3
	Fluid Management	Balanced Crystalloids versus Saline in Critically Ill Adults	SMART-MED/SMART-SURG	https://www.wikijournalclub.org/wiki/SMART-MED_and_SMART-SURG
	Fluid Management	Balanced Crystalloids versus Saline in Noncritically Ill Adults	SALT-ED	https://www.wikijournalclub.org/wiki/SALT-ED
	Ventilation	Comparison of two fluid-management strategies in acute lung injury	FACTT	https://www.wikijournalclub.org/wiki/FACTT
	Trauma	Complications of nonoperative management of high-grade blunt hepatic injuries	Kozar et al 2005
	Hemodynamics	Drotrecogin Alfa (Activated) in Adults with Septic Shock	PROWESS-SHOCK	https://www.wikijournalclub.org/wiki/PROWESS-SHOCK
\|	General	Early Lactate-Guided Therapy in Intensive Care Unit Patients: A Multicenter, Open-Label, Randomized Controlled Trial	LACTATE
	Air/Oxygenation	Effect of Conservative vs Conventional Oxygen Therapy on Mortality Among Patients in an Intensive Care Unit	OXYGEN-ICU	https://www.wikijournalclub.org/wiki/OXYGEN-ICU
	Hemodynamics	Effect of Hydrocortisone on Development of Shock Among Patients With Severe Sepsis	HYPRESS	https://www.wikijournalclub.org/wiki/HYPRESS
	Air/Oxygenation	Effect of Noninvasive Ventilation Delivered by Helmet vs Face Mask on the Rate of Endotracheal Intubation in Patients With Acute Respiratory Distress Syndrome	Patel et al 2016
	Trauma	Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial	CRASH-2	https://www.wikijournalclub.org/wiki/CRASH-2
	Ventilation	Efficacy and Safety of Corticosteroids for Persistent Acute Respiratory Distress Syndrome	Steinberg et al 2006
	Cardiac Intensive Care	Efficacy and safety of immediate angioplasty versus ischemia-guided management after thrombolysis in acute myocardial infarction in areas with very long transfer distances results of the NORDISTEMI (NORwegian study on DIstrict treatment of ST-elevation myocardial infarction)	NORDSTEMI
	Air/Oxygenation	First Pass Success Without Hypoxemia Is Increased With the Use of Apneic Oxygenation During Rapid Sequence Intubation in the Emergency Department	Sakles et al 2016
	Ventilation	High-frequency oscillation in early acute respiratory distress syndrome.	OSCILLATE	https://www.wikijournalclub.org/wiki/OSCILLATE
	Ventilation	Higher versus Lower Positive End-Expiratory Pressures in Patients with the Acute Respiratory Distress Syndrome	Brower et al 2004
	Fluid Management	Hydrocortisone Therapy for Patients with Septic Shock	CORTICUS	https://www.wikijournalclub.org/wiki/CORTICUS
	Trauma	Immediate total-body CT scanning versus conventional imaging and selective CT scanning in patients with severe trauma (REACT-2): a randomised controlled trial	REACT-2
	Cardiac Intensive Care	Lenient versus strict rate control in patients with atrial fibrillation	RACE II	https://www.wikijournalclub.org/wiki/RACE_II
	Trauma	Management of post-traumatic retained hemothorax: a prospective, observational, multicenter AAST study	AAST
	Ventilation	Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome	ACURASYS	https://www.wikijournalclub.org/wiki/ACURASYS
	Trauma	Normal electrocardiography and serum troponin I levels preclude the presence of clinically significant blunt cardiac injury	Velmahos GC et al 2003
	Ventilation	Prone positioning in severe acute respiratory distress syndrome.	PROSEVA	https://www.wikijournalclub.org/wiki/PROSEVA
	Cardiac Intensive Care	Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial	RIVAL	https://www.wikijournalclub.org/wiki/RIVAL
	Cardiac Intensive Care	Randomized trial of preventive angioplasty in myocardial infarction	PRAMI	https://www.wikijournalclub.org/wiki/PRAMI
	Trauma	Splenic embolization revisited: a multicenter review	Haan JM et al 2004
	Cardiac Intensive Care	Strategies for multivessel revascularization in patients with diabetes	FREEDOM	https://www.wikijournalclub.org/wiki/FREEDOM
	Cardiac Intensive Care	The effect of digoxin on mortality and morbidity in patients with heart failure	DIG	https://www.wikijournalclub.org/wiki/DIG
	Cardiac Intensive Care	The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators	RALES	https://www.wikijournalclub.org/wiki/RALES
	Trauma	The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks	PROMMTT
	Trauma	Thrombelastography-Based Dosing of Enoxaparin for Thromboprophylaxis in Trauma and Surgical Patients: A Randomized Clinical Trial	Connelly CR et al 2016
	Cardiac Intensive Care	Thrombus Aspiration during Percutaneous coronary intervention in Acute myocardial infarction Study (TAPAS)--study design	TAPAS
	Trauma	Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial	PROPPR	https://www.wikijournalclub.org/wiki/PROPPR
	Ventilation	Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome	ARDSNet	https://www.wikijournalclub.org/wiki/ARDSNet
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