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Landmark Clinical Trials: Critical Care

Critical Care
Neuro IR
GI Procedures
Pain Management
GU Procedures
Pediatric IR
Interventional Oncology
Vascular Procedures
  Area Topic CTS JP Trial Name Original Article Wiki Journal Club CTS Author JP Author Attending Reviewer
Fluid Management A Comparison of Albumin and Saline for Fluid Resuscitation in the Intensive Care Unit SAFE https://www.wikijournalclub.org/wiki/SAFE
Cardiac Intensive Care A comparison of rate control and rhythm control in patients with atrial fibrillation. AFFIRM https://www.wikijournalclub.org/wiki/AFFIRM
Cardiac Intensive Care Apixaban versus warfarin in patients with atrial fibrillation ARISTOTLE https://www.wikijournalclub.org/wiki/ARISTOTLE
Hemodynamics Application of the Third International Consensus Definitions for Sepsis (Sepsis-3) Classification: a retrospective population-based cohort study SEPSIS-3
Fluid Management Balanced Crystalloids versus Saline in Critically Ill Adults SMART-MED/SMART-SURG https://www.wikijournalclub.org/wiki/SMART-MED_and_SMART-SURG
Fluid Management Balanced Crystalloids versus Saline in Noncritically Ill Adults SALT-ED https://www.wikijournalclub.org/wiki/SALT-ED
Ventilation Comparison of two fluid-management strategies in acute lung injury FACTT https://www.wikijournalclub.org/wiki/FACTT
Trauma Complications of nonoperative management of high-grade blunt hepatic injuries Kozar et al 2005
Hemodynamics Drotrecogin Alfa (Activated) in Adults with Septic Shock PROWESS-SHOCK https://www.wikijournalclub.org/wiki/PROWESS-SHOCK
| General Early Lactate-Guided Therapy in Intensive Care Unit Patients: A Multicenter, Open-Label, Randomized Controlled Trial LACTATE
Air/Oxygenation Effect of Conservative vs Conventional Oxygen Therapy on Mortality Among Patients in an Intensive Care Unit OXYGEN-ICU https://www.wikijournalclub.org/wiki/OXYGEN-ICU
Hemodynamics Effect of Hydrocortisone on Development of Shock Among Patients With Severe Sepsis HYPRESS https://www.wikijournalclub.org/wiki/HYPRESS
Air/Oxygenation Effect of Noninvasive Ventilation Delivered by Helmet vs Face Mask on the Rate of Endotracheal Intubation in Patients With Acute Respiratory Distress Syndrome Patel et al 2016
Trauma Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial CRASH-2 https://www.wikijournalclub.org/wiki/CRASH-2
Ventilation Efficacy and Safety of Corticosteroids for Persistent Acute Respiratory Distress Syndrome Steinberg et al 2006
Cardiac Intensive Care Efficacy and safety of immediate angioplasty versus ischemia-guided management after thrombolysis in acute myocardial infarction in areas with very long transfer distances results of the NORDISTEMI (NORwegian study on DIstrict treatment of ST-elevation myocardial infarction) NORDSTEMI
Air/Oxygenation First Pass Success Without Hypoxemia Is Increased With the Use of Apneic Oxygenation During Rapid Sequence Intubation in the Emergency Department Sakles et al 2016
Ventilation High-frequency oscillation in early acute respiratory distress syndrome. OSCILLATE https://www.wikijournalclub.org/wiki/OSCILLATE
Ventilation Higher versus Lower Positive End-Expiratory Pressures in Patients with the Acute Respiratory Distress Syndrome Brower et al 2004
Fluid Management Hydrocortisone Therapy for Patients with Septic Shock CORTICUS https://www.wikijournalclub.org/wiki/CORTICUS
Trauma Immediate total-body CT scanning versus conventional imaging and selective CT scanning in patients with severe trauma (REACT-2): a randomised controlled trial REACT-2
Cardiac Intensive Care Lenient versus strict rate control in patients with atrial fibrillation RACE II https://www.wikijournalclub.org/wiki/RACE_II
Trauma Management of post-traumatic retained hemothorax: a prospective, observational, multicenter AAST study AAST
Ventilation Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome ACURASYS https://www.wikijournalclub.org/wiki/ACURASYS
Trauma Normal electrocardiography and serum troponin I levels preclude the presence of clinically significant blunt cardiac injury Velmahos GC et al 2003
Ventilation Prone positioning in severe acute respiratory distress syndrome. PROSEVA https://www.wikijournalclub.org/wiki/PROSEVA
Cardiac Intensive Care Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial RIVAL https://www.wikijournalclub.org/wiki/RIVAL
Cardiac Intensive Care Randomized trial of preventive angioplasty in myocardial infarction PRAMI https://www.wikijournalclub.org/wiki/PRAMI
Trauma Splenic embolization revisited: a multicenter review Haan JM et al 2004
Cardiac Intensive Care Strategies for multivessel revascularization in patients with diabetes FREEDOM https://www.wikijournalclub.org/wiki/FREEDOM
Cardiac Intensive Care The effect of digoxin on mortality and morbidity in patients with heart failure DIG https://www.wikijournalclub.org/wiki/DIG
Cardiac Intensive Care The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators RALES https://www.wikijournalclub.org/wiki/RALES
Trauma The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks PROMMTT
Trauma Thrombelastography-Based Dosing of Enoxaparin for Thromboprophylaxis in Trauma and Surgical Patients: A Randomized Clinical Trial Connelly CR et al 2016
Cardiac Intensive Care Thrombus Aspiration during Percutaneous coronary intervention in Acute myocardial infarction Study (TAPAS)--study design TAPAS
Trauma Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial PROPPR https://www.wikijournalclub.org/wiki/PROPPR
Ventilation Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome ARDSNet https://www.wikijournalclub.org/wiki/ARDSNet
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